Catalog Number - 85518-PG1

The 85518‑PG1 Cogent RP C18 ABX™ Guard Column Cartridges are engineered to extend column life in LC‑MS and low‑flow analytical workflows, providing reliable protection against particulates, strongly retained analytes, and sample matrix contamination.

Packed with 5 µm RP C18 ABX™ stationary phase, these cartridges use bulky end‑capping on high‑purity silica, delivering stable performance across extreme pH conditions (2–12).

Designed for 2.1 mm ID Columns (LC‑MS / Low Flow)

• Optimized for:

  • 2.1 mm ID LC‑MS columns

  • low‑flow analytical HPLC systems

Typical Flow Rate Range

• ~0.2–0.3 mL/min

✅ Requires precise low‑flow pump control and low system volume compatibility

✅ Maintains chromatographic integrity under LC‑MS conditions

Purpose of Guard Columns

• Protect analytical columns from:

  • Particulate contamination

  • Strongly retained acidic and basic compounds

  • Matrix fouling and buildup

• Extend column lifetime

• Maintain retention reproducibility and peak shape

• Reduce downtime and replacement costs

5 µm Guard Media – Durable LC‑MS Protection

• Matches standard analytical particle sizes

• Provides balanced efficiency and robustness

• Ideal for routine LC‑MS workflows

✅ Preferred for long service life and method reproducibility

Why Choose RP C18 ABX™ Guard Cartridges (5 µm)

Matched Extreme pH Chemistry

• Same ABX™ stationary phase as analytical column

• Maintains retention behavior and selectivity

• Supports full pH 2–12 operation

Enhanced LC‑MS System Protection

• Protects:

  • Analytical column

  • LC‑MS interface and detector

• Reduces contamination reaching sensitive components

Workflow Efficiency

• Minimizes column replacement frequency

• Improves instrument uptime and analytical consistency

Cogent RP C18 ABX™ Advantages

Extreme pH Stability

• Reliable across pH 2–12

• Ideal for acidic and basic separations

Bulky End‑Capping

• Minimizes secondary interactions

• Improves peak symmetry and reproducibility

Durable Construction

• Stainless steel cartridge body

• Stainless steel frits

• PEEK frit caps

✅ Designed for high‑sensitivity LC‑MS environments

Important Usage Notes

• ⚠️ Must be used with a compatible guard column holder system

• Designed specifically for 2.1 mm LC‑MS and low‑flow HPLC systems

• Suitable for extreme pH workflows (pH 2–12)

• Replace regularly to maintain optimal system protection

Helpful Resource & Link

• 👉 View guard column holders and compatibility options for these cartridges